Mark J. Macielag: search on Z-Library

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1

Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives

Bin Zhu, Brett A. Marinelli, Darren Abbanat, Barbara D. Foleno, Todd C. Henninger, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 204 KB

english, 2006

2

GPR120 agonists for the treatment of diabetes: a patent review (2014-present)

Zhang, Xuqing, Macielag, Mark J.

Journal:

Expert Opinion on Therapeutic Patents

Year:

2020

File:

PDF, 1.91 MB

2020

3

An enantioselective method for reductive alkylation of aromatic carboxylic acid derivatives. Examination of the factors that provide stereoselectivity

Schultz, Arthur G., Macielag, Mark., Sundararaman, Padmanabhan., Taveras, Arthur G., Welch, Martha.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 2.47 MB

english, 1988

4

The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL)

Zhu, Bin, Connolly, Peter J., Zhang, Sui-Po, Chevalier, Kristen M., Milligan, Cynthia M., Flores, Christopher M., Macielag, Mark J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.67 MB

2020

5

An Improved Non-chromatographic Scale-up Synthesis of a New 1,6,7,8-Substituted-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid as a Potent Bacterial Topoisomerase Inhibitor

Li, Xun, Youells, Scott, Russell, Ronald K., Roessler, Armin, Schmid, Tobias, Faessler, Roger, Weidner-Wells, Michele A., Grant, Eugene B., Macielag, Mark J.

Journal:

Organic Preparations and Procedures International

Year:

2010

Language:

english

File:

PDF, 296 KB

english, 2010

6

The enantioselective conversion of ortho-substituted benzoic acids to chiral cyclohexane derivatives

Arthur G. Schultz, Padmanabhan Sundararaman, Mark Macielag, Frank P. Lavieri, Martha Welch

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 197 KB

english, 1985

7

The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones

Michele A. Weidner-Wells, Harvey M. Werblood, Raul Goldschmidt, Karen Bush, Barbara D. Foleno, Jamese J. Hilliard, John Melton, Ellyn Wira, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 258 KB

english, 2004

8

Pyrroloquinolone PDE5 Inhibitors with Improved Pharmaceutical Profiles for Clinical Studies on Erectile Dysfunction

Jiang, Weiqin, Guan, Jihua, Macielag, Mark J., Zhang, Suying, Qiu, Yuhong, Kraft, Patricia, Bhattacharjee, Sheela, John, T. Matthew, Haynes-Johnson, Donna, Lundeen, Scott, Sui, Zhihua

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 243 KB

english, 2005

9

Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists

Matthews, Jay M., McNally, James J., Connolly, Peter J., Xia, Mingde, Zhu, Bin, Black, Shawn, Chen, Cailin, Hou, Cuifen, Liang, Yin, Tang, Yuting, Macielag, Mark J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 5.82 MB

english, 2016

10

Synthesis and biological activities of novel β-Carbolines as PDE5 inhibitors

Zhihua Sui, Jihua Guan, Mark J. Macielag, Weiqin Jiang, Yuhong Qiu, Patricia Kraft, Sheela Bhattacharjee, T.Matthew John, Elizabeth Craig, Donna Haynes-Johnson, Joanna Clancy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 193 KB

english, 2003

11

Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859

Yuhong Qiu, Sheela Bhattacharjee, Patricia Kraft, T.Mathew John, Elizabeth Craig, Donna Haynes-Johnson, Jihua Guan, Weiqin Jiang, Mark Macielag, Zhihua Sui, Joanna Clancy, Scott Lundeen

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 355 KB

english, 2003

12

Substituted Salicylanilides as Inhibitors of Two-Component Regulatory Systems in Bacteria

Macielag, Mark J., Demers, James P., Fraga-Spano, Stephanie A., Hlasta, Dennis J., Johnson, Sigmond G., Kanojia, Ramesh M., Russell, Ronald K., Sui, Zhihua, Weidner-Wells, Michele A., Werblood, Harvey

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 119 KB

english, 1998

13

Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists

Zhu, Bin, Matthews, Jay M., Xia, Mingde, Black, Shawn, Chen, Cailin, Hou, Cuifen, Liang, Yin, Tang, Yuting, Macielag, Mark J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 5.83 MB

english, 2016

14

Novel erythromycin A derivatives: synthesis of 11,12-benzoxazine ketolides

Bin Zhu, Amy Maden, Mark J. Macielag

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

15

Enantioselective Birch reduction and reductive alkylations of chiral 2-phenylbenzoic acid derivatives. Application to the synthesis of hydrofluoren-9-ones, hydrophenanthren-9-ones, and (-)-(1R,2R)-2-phenylcyclohexanamine

Schultz, Arthur G., Macielag, Mark, Podhorez, David E., Suhadolnik, Joseph C., Kullnig, Rudolph K.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 1.27 MB

english, 1988

16

Furoyl and Benzofuroyl Pyrroloquinolones as Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction

Jiang, Weiqin, Sui, Zhihua, Macielag, Mark J., Walsh, Shawn P., Fiordeliso, James J., Lanter, James C., Guan, Jihua, Qiu, Yuhong, Kraft, Patricia, Bhattacharjee, Sheela, Craig, Elizabeth, Haynes-Johns

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 113 KB

english, 2003

17

Anti-MRSA β-lactams in development, with a focus on ceftobiprole: the first anti-MRSA β-lactam to demonstrate clinical efficacy

Bush, Karen, Heep, Markus, Macielag, Mark J, Noel, Gary J

Journal:

Expert Opinion on Investigational Drugs

Year:

2007

Language:

english

File:

PDF, 243 KB

english, 2007

18

‘Superbugs’: new antibacterials in the pipeline

Bush, Karen, Macielag, Mark, Clancy, Joanna

Journal:

Expert Opinion on Emerging Drugs

Year:

2000

Language:

english

File:

PDF, 300 KB

english, 2000

19

Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones

Bin Zhu, Brett A. Marinelli, Raul Goldschmidt, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 695 KB

english, 2009

20

Synthesis and Antibacterial Activity of Pyrroloaryl-Substituted Oxazolidinones.

Steven D. Paget, Barbara D. Foleno, Christine M. Boggs, Raul M. Goldschmidt, Dennis J. Hlasta, Michele A. Weidner-Wells, Harvey M. Werblood, Ellyn Wira, Karen Bush, Mark J. Macielag

Journal:

Year:

2004

File:

PDF, 156 KB

2004

21

Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides

Eugene B. Grant, Deodialsingh Guiadeen, Darren Abbanat, Barbara D. Foleno, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 167 KB

english, 2006

22

A Convenient Synthesis of 3,5- bis (Trifluoromethyl)Salicylic Acid

Sui, Zhihua, Macielag, Mark J.

Journal:

Synthetic Communications

Year:

1997

Language:

english

File:

PDF, 274 KB

english, 1997

23

Structure−Activity Relationships of N -Acyl Pyrroloquinolone PDE-5 Inhibitors

Lanter, James C., Sui, Zhihua, Macielag, Mark J., Fiordeliso, James J., Jiang, Weiqin, Qiu, Yuhong, Bhattacharjee, Sheela, Kraft, Patricia, John, T. Mathew, Haynes-Johnson, Donna, Craig, Elizabeth, Cl

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 97 KB

english, 2004

24

Pyrimidinylpyrroloquinolones as Highly Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction

Sui, Zhihua, Guan, Jihua, Macielag, Mark J., Jiang, Weiqin, Zhang, Suying, Qiu, Yuhong, Kraft, Patricia, Bhattacharjee, Sheela, John, T. Matthew, Haynes-Johnson, Donna, Clancy, Joanna

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 84 KB

english, 2002

25

Inhibitors of bacterial two-component signalling systems

Macielag, Mark J, Goldschmidt, Raul

Journal:

Expert Opinion on Investigational Drugs

Year:

2000

Language:

english

File:

PDF, 162 KB

english, 2000

26

Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes

Zhang, Xuqing, Cai, Chaozhong, Sui, Zhihua, Macielag, Mark, Wang, Yuanping, Yan, Wen, Suckow, Arthur, Hua, Hong, Bell, Austin, Haug, Peter, Clapper, Wilma, Jenkinson, Celia, Gunnet, Joseph, Leonard, J

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 510 KB

english, 2017

27

Synthesis and Antibacterial Activity of C-6 Carbamate Ketolides, a Novel Series of Orally Active Ketolide Antibiotics.

Todd C. Henninger, Xiaodong Xu, Darren Abbanat, Ellen Z. Baum, Barbara D. Foleno, Jamese J. Hilliard, Karen Bush, Dennis J. Hlasta, Mark J. Macielag

Journal:

Year:

2004

Language:

english

File:

PDF, 28 KB

english, 2004

28

The Synthesis and Antimicrobial Evaluation of a New Series of isoxazolinyl Oxazolidinones.

Michele A. Weidner-Wells, Harvey M. Werblood, Raul Goldschmidt, Karen Bush, Barbara D. Foleno, Jamese J. Hilliard, John Melton, Ellyn Wira, Mark J. Macielag

Journal:

Year:

2004

File:

PDF, 22 KB

2004

29

Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

Robicsek, Ari, Strahilevitz, Jacob, Jacoby, George A, Macielag, Mark, Abbanat, Darren, Hye Park, Chi, Bush, Karen, Hooper, David C

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 208 KB

english, 2005

30

Intramolecular cycloadditions to oxyallyl zwitterions generated from photorearrangements of 2,5-cyclohexadien-1-ones

Schultz, Arthur G., Macielag, Mark, Plummer, Mark

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 743 KB

english, 1988

31

Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB 1 R Inverse Agonists

Zhang, Yue-Mei, Greco, Michael, Le Blanc, Tonya, Lang, Wensheng, Kauffman, Jack, Masucci, John, Murray, William V., Demarest, Keith, Macielag, Mark Joseph

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.65 MB

2020

32

Capillary zone electrophoresis studies of motilin peptides: Effects of charge, hydrophobicity, secondary structure and length

James R. Florance, Zenon D. Konteatis, Mark J. Macielag, Ralph A. Lessor, Alphonse Galdes

Journal:

Journal of Chromatography A

Year:

1991

Language:

english

File:

PDF, 485 KB

english, 1991

33

New β-lactam antibiotics and β-lactamase inhibitors

Bush, Karen, Macielag, Mark J

Journal:

Expert Opinion on Therapeutic Patents

Year:

2010

Language:

english

File:

PDF, 720 KB

english, 2010

34

Crystallization of a Cephalosporin and an ERR-1: Assembly of an Inexpensive Crystallization Platform

Wells, Kenneth M., Beauchamp, Derek A., Fermier, Adam, Wu, Wenju, Mehrman, Steven, Youells, Scott, Hu, Zhiyong, Li, Xun, Macielag, Mark J., Bignan, Gilles, Xu, Guozhang, Zhao, Bao-Ping, Huang, Lian, W

Journal:

Crystal Growth & Design

Year:

2013

Language:

english

File:

PDF, 695 KB

english, 2013

35

Kirk-Othmer Encyclopedia of Chemical Technology || Antibacterial Agents, Overview

Macielag, Mark J.

Year:

2000

Language:

english

File:

PDF, 214 KB

english, 2000

36

ChemInform Abstract: An Improved Non-chromatographic Scale-up Synthesis of a New 1,6,7,8-Substituted-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid (V) as a Potent Bacterial Topoisomerase Inhibitor.

Xun Li, Scott Youells, Ronald K. Russell, Armin Roessler, Tobias Schmid, Roger Faessler, Michele A. Weidner-Wells, Eugene B. Grant, Mark J. Macielag

Journal:

Year:

2010

File:

PDF, 28 KB

2010

37

Meeting Highlights Anti-infectives: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy New Orleans, Louisiana, USA, September 15 – 18, 1996

Barrett, John F, Macielag, Mark J, Fernandez, Jeffrey, Hlasta, Dennis J

Journal:

Expert Opinion on Investigational Drugs

Year:

1996

Language:

english

File:

PDF, 559 KB

english, 1996

38

Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes

Xiaodong Xu, Todd Henninger, Darren Abbanat, Karen Bush, Barbara Foleno, Jamese Hilliard, Mark Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

39

The regioselectivity and stereoselectivity of the photorearrangement of 3-methoxy-4- methoxycarbonyl-4-methyl-2,5-cyclohexadien-1-one

Arthur G. Schultz, Frank P. Lavieri, Mark Macielag

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 236 KB

english, 1986

40

Progesterone receptor agonists and antagonists

Allan, George, Macielag, Mark

Journal:

Expert Opinion on Therapeutic Patents

Year:

1999

Language:

english

File:

PDF, 86 KB

english, 1999

41

Amidino benzimidazole inhibitors of bacterial two-component systems

Michele A. Weidner-Wells, Kwasi A. Ohemeng, Van N. Nguyen, Stephanie Fraga-Spano, Mark J. Macielag, Harvey M. Werblood, Barbara D. Foleno, Glenda C. Webb, John F. Barrett, Dennis J. Hlasta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 142 KB

english, 2001

42

New approaches in the treatment of bacterial infections

Karen Bush, Mark Macielag

Journal:

Current Opinion in Chemical Biology

Year:

2000

Language:

english

File:

PDF, 136 KB

english, 2000

43

d-Amino acid and alanine scans of the bioactive portion of porcine motilin

Theo L. Peeters, Mark J. Macielag, Inge Depoortere, Zenon D. Konteatis, James R. Florance, Ralph A. Lessor, Alphonse Galdes

Journal:

Year:

1992

Language:

english

File:

PDF, 520 KB

english, 1992

44

Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements

Steven D. Paget, Christine M. Boggs, Barbara D. Foleno, Raul M. Goldschmidt, Dennis J. Hlasta, Michele A. Weidner-Wells, Harvey M. Werblood, Karen Bush, Mark J. Macielag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

45

Preparation of Erythromycin Analogs Having Functional Groups at C-15

Ashley, Gary W, Burlingame, Mark, Desai, Ruchir, Fu, Hong, Leaf, Tim, Licari, Peter J, Tran, Chau, Abbanat, Darren, Bush, Karen, Macielag, Mark

Journal:

The Journal of Antibiotics

Year:

2006

Language:

english

File:

PDF, 155 KB

english, 2006

46

Synthesis and in vitro evaluation of [Leu13]porcine motilin fragments

Mark J. Macielag, Theo L. Peeters, Zenon D. Konteatis, James R. Florance, Inge Depoortere, Ralph A. Lessor, Lance A. Bare, Yea-Shun Cheng, Alphonse Galdes

Journal:

Year:

1992

Language:

english

File:

PDF, 471 KB

english, 1992

47

ChemInform Abstract: Amidino Benzimidazole Inhibitors of Bacterial Two-Component Systems

Michele A. Weidner-Wells, Kwasi A. Ohemeng, Van N. Nguyen, Stephanie Fraga-Spano, Mark J. Macielag, Harvey M. Werblood, Barbara D. Foleno, Glenda C. Webb, John F. Barrett, Dennis J. Hlasta

Journal:

Year:

2001

File:

PDF, 32 KB

2001

48

15-Amido Erythromycins: Synthesis and in Vitro Activity of a New Class of Macrolide Antibiotics

Shaw, Simon J, Abbanat, Darren, Ashley, Gary W, Bush, Karen, Foleno, Barbara, Macielag, Mark, Zhang, Dan, Myles, David C

Journal:

The Journal of Antibiotics

Year:

2005

File:

PDF, 151 KB

2005

49

Birch reduction and reductive alkylation of benzonitriles and benzamides

Schultz, Arthur G., Macielag, Mark

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 728 KB

english, 1986

50

2,5-Cyclohexadien-1-one to bicyclo[3.1.0]hexenone photorearrangement. Development of the reaction for use in organic synthesis

Schultz, Arthur G., Lavieri, Frank P., Macielag, Mark, Plummer, Mark

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 1.35 MB

english, 1987

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